Assay Detail
Functional
CHEMBL3737099
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Antiproliferative activity against human K562 cells after 48 hrs by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and preliminary biological studies of pyrrolidine derivatives as Mcl-1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.77 | 5.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51483 | GOSSYPOL | 3.0 | 1 | 5.23 |
| CHEMBL3736193 | — | — | 1 | 4.66 |
| CHEMBL3736460 | — | — | 1 | 4.66 |
| CHEMBL3735093 | — | — | 1 | 4.65 |
| CHEMBL3735206 | — | — | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51483 | GOSSYPOL | IC50 | = | 5910.0 | nM | 5.23 |
| CHEMBL3736193 | — | IC50 | = | 22100.0 | nM | 4.66 |
| CHEMBL3736460 | — | IC50 | = | 21900.0 | nM | 4.66 |
| CHEMBL3735093 | — | IC50 | = | 22400.0 | nM | 4.65 |
| CHEMBL3735206 | — | IC50 | = | 23000.0 | nM | 4.64 |