Assay Detail
Binding
CHEMBL3737170
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CA2 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay
35
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 35 | 7.06 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | 8.52 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 8.10 |
| CHEMBL328560 | SULTHIAME | 3.0 | 1 | 8.05 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 8.05 |
| CHEMBL73962 | BENZOLAMIDE | — | 1 | 8.05 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 8.00 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.85 |
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 7.82 |
| CHEMBL750 | ZONISAMIDE | 4.0 | 1 | 7.46 |
| CHEMBL26 | SULPIRIDE | 3.0 | 1 | 7.40 |
| CHEMBL865 | VALDECOXIB | 4.0 | 1 | 7.37 |
| CHEMBL435 | HYDROCHLOROTHIAZIDE | 4.0 | 1 | 6.54 |
| CHEMBL310671 | SACCHARIN | 3.0 | 1 | 5.22 |
| CHEMBL183419 | CYANIDE | — | 1 | 4.70 |
| CHEMBL1161700 | CYANATE | — | 1 | 4.52 |
| CHEMBL1200739 | HYDROGEN SULFIDE | — | 1 | 4.40 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | - |
| CHEMBL21485 | PHENYLBORONIC ACID | — | 1 | - |
| CHEMBL2206489 | PHENYLARSONIC ACID SODIUM SALT | — | 1 | - |
| CHEMBL1362 | FLUORIDE ION | 3.0 | 1 | - |
| CHEMBL355001 | SULFAMIDE | — | 1 | - |
| CHEMBL232233 | SODIUM SULFAMATE | — | 1 | - |
| CHEMBL1161634 | PERCHLORATE | — | 1 | - |
| CHEMBL572964 | SULFURIC ACID | -1.0 | 1 | - |
| CHEMBL1161699 | SULFUROUS ACID | — | 1 | - |
| CHEMBL1161681 | NITROUS ACID | 4.0 | 1 | - |
| CHEMBL186200 | — | — | 1 | - |
| CHEMBL1161632 | BICARBONATE | 3.0 | 2 | - |
| CHEMBL79455 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL220491 | BRINZOLAMIDE | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL328560 | SULTHIAME | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL73962 | BENZOLAMIDE | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL77517 | INDISULAM | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL750 | ZONISAMIDE | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL26 | SULPIRIDE | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL865 | VALDECOXIB | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL435 | HYDROCHLOROTHIAZIDE | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL310671 | SACCHARIN | Ki | = | 5950.0 | nM | 5.22 |
| CHEMBL183419 | CYANIDE | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL1161700 | CYANATE | Ki | = | 30000.0 | nM | 4.52 |
| CHEMBL1200739 | HYDROGEN SULFIDE | Ki | = | 40000.0 | nM | 4.40 |
| CHEMBL1231821 | HYDROCHLORIC ACID | Ki | = | 200000000.0 | nM | - |
| CHEMBL1231461 | BROMIDE | Ki | = | 63000000.0 | nM | - |
| CHEMBL1233550 | IODIDE | Ki | = | 26000000.0 | nM | - |
| CHEMBL84336 | THIOCYANIC ACID | Ki | = | 1600000.0 | nM | - |
| CHEMBL79455 | — | Ki | = | 1500000.0 | nM | - |
| CHEMBL1161632 | BICARBONATE | Ki | = | 85000000.0 | nM | - |
| CHEMBL1161632 | BICARBONATE | Ki | = | 73000000.0 | nM | - |
| CHEMBL186200 | — | Ki | = | 35000000.0 | nM | - |
| CHEMBL1161681 | NITROUS ACID | Ki | = | 63000000.0 | nM | - |
| CHEMBL1161699 | SULFUROUS ACID | Ki | = | 89000000.0 | nM | - |
| CHEMBL572964 | SULFURIC ACID | Ki | > | 200000000.0 | nM | - |
| CHEMBL1161634 | PERCHLORATE | Ki | > | 200000000.0 | nM | - |
| CHEMBL232233 | SODIUM SULFAMATE | Ki | = | 390000.0 | nM | - |
| CHEMBL1362 | FLUORIDE ION | Ki | > | 300000000.0 | nM | - |
| CHEMBL21485 | PHENYLBORONIC ACID | Ki | = | 23100000.0 | nM | - |
| CHEMBL2206489 | PHENYLARSONIC ACID SODIUM SALT | Ki | = | 49200000.0 | nM | - |
| CHEMBL355001 | SULFAMIDE | Ki | = | 1130000.0 | nM | - |
| CHEMBL118 | CELECOXIB | Ki | = | 21.0 | nM | - |