Assay Detail
Binding
CHEMBL3737173
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Inhibition of Chionodraco hamatus alphaCA incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay
35
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Chionodraco hamatus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 35 | 6.38 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 7.41 |
| CHEMBL328560 | SULTHIAME | 3.0 | 1 | 7.30 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.30 |
| CHEMBL750 | ZONISAMIDE | 4.0 | 1 | 7.28 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.19 |
| CHEMBL73962 | BENZOLAMIDE | — | 1 | 7.18 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.18 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 7.11 |
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | 7.05 |
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 6.42 |
| CHEMBL26 | SULPIRIDE | 3.0 | 1 | 6.29 |
| CHEMBL865 | VALDECOXIB | 4.0 | 1 | 6.14 |
| CHEMBL435 | HYDROCHLOROTHIAZIDE | 4.0 | 1 | 6.06 |
| CHEMBL310671 | SACCHARIN | 3.0 | 1 | 6.06 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 6.06 |
| CHEMBL355001 | SULFAMIDE | — | 1 | 5.05 |
| CHEMBL2206489 | PHENYLARSONIC ACID SODIUM SALT | — | 1 | 5.05 |
| CHEMBL21485 | PHENYLBORONIC ACID | — | 1 | 5.00 |
| CHEMBL232233 | SODIUM SULFAMATE | — | 1 | 4.11 |
| CHEMBL1362 | FLUORIDE ION | 3.0 | 1 | - |
| CHEMBL1161634 | PERCHLORATE | — | 1 | - |
| CHEMBL572964 | SULFURIC ACID | -1.0 | 1 | - |
| CHEMBL1161699 | SULFUROUS ACID | — | 1 | - |
| CHEMBL1200739 | HYDROGEN SULFIDE | — | 1 | - |
| CHEMBL1161681 | NITROUS ACID | 4.0 | 1 | - |
| CHEMBL186200 | — | — | 1 | - |
| CHEMBL1161632 | BICARBONATE | 3.0 | 2 | - |
| CHEMBL79455 | — | — | 1 | - |
| CHEMBL183419 | CYANIDE | — | 1 | - |
| CHEMBL84336 | THIOCYANIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 39.1 | nM | 7.41 |
| CHEMBL328560 | SULTHIAME | Ki | = | 49.5 | nM | 7.30 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 49.9 | nM | 7.30 |
| CHEMBL750 | ZONISAMIDE | Ki | = | 52.9 | nM | 7.28 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 65.4 | nM | 7.18 |
| CHEMBL73962 | BENZOLAMIDE | Ki | = | 65.3 | nM | 7.18 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 77.6 | nM | 7.11 |
| CHEMBL220491 | BRINZOLAMIDE | Ki | = | 88.1 | nM | 7.05 |
| CHEMBL77517 | INDISULAM | Ki | = | 385.0 | nM | 6.42 |
| CHEMBL26 | SULPIRIDE | Ki | = | 511.0 | nM | 6.29 |
| CHEMBL865 | VALDECOXIB | Ki | = | 726.0 | nM | 6.14 |
| CHEMBL310671 | SACCHARIN | Ki | = | 877.0 | nM | 6.06 |
| CHEMBL435 | HYDROCHLOROTHIAZIDE | Ki | = | 866.0 | nM | 6.06 |
| CHEMBL118 | CELECOXIB | Ki | = | 866.0 | nM | 6.06 |
| CHEMBL355001 | SULFAMIDE | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL2206489 | PHENYLARSONIC ACID SODIUM SALT | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL21485 | PHENYLBORONIC ACID | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL232233 | SODIUM SULFAMATE | Ki | = | 77000.0 | nM | 4.11 |
| CHEMBL79455 | — | Ki | = | 850000.0 | nM | - |
| CHEMBL1161634 | PERCHLORATE | Ki | > | 200000000.0 | nM | - |
| CHEMBL572964 | SULFURIC ACID | Ki | = | 670000.0 | nM | - |
| CHEMBL1161699 | SULFUROUS ACID | Ki | = | 740000.0 | nM | - |
| CHEMBL1200739 | HYDROGEN SULFIDE | Ki | = | 870000.0 | nM | - |
| CHEMBL1161681 | NITROUS ACID | Ki | = | 820000.0 | nM | - |
| CHEMBL186200 | — | Ki | = | 800000.0 | nM | - |
| CHEMBL1161632 | BICARBONATE | Ki | = | 1020000.0 | nM | - |
| CHEMBL1161632 | BICARBONATE | Ki | = | 730000.0 | nM | - |
| CHEMBL183419 | CYANIDE | Ki | = | 790000.0 | nM | - |
| CHEMBL84336 | THIOCYANIC ACID | Ki | = | 950000.0 | nM | - |
| CHEMBL1161700 | CYANATE | Ki | = | 580000.0 | nM | - |
| CHEMBL1233550 | IODIDE | Ki | = | 700000.0 | nM | - |
| CHEMBL1231461 | BROMIDE | Ki | = | 1210000.0 | nM | - |
| CHEMBL1362 | FLUORIDE ION | Ki | = | 910000.0 | nM | - |
| CHEMBL1231821 | HYDROCHLORIC ACID | Ki | = | 930000.0 | nM | - |