Assay Detail
Binding
CHEMBL3737700
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Inhibition of human recombinant SphK2 preincubated for 5 mins followed by substrate addition measured for 60 mins by plate reader assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel sphingosine kinase 1 inhibitors via structure-based hierarchical virtual screening
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.57 | 4.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL322333 | DIMETHYLSPINGOSINE | — | 1 | 4.79 |
| CHEMBL3735192 | — | — | 1 | 4.77 |
| CHEMBL3735039 | — | — | 1 | 4.50 |
| CHEMBL3736205 | — | — | 1 | 4.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL322333 | DIMETHYLSPINGOSINE | IC50 | = | 16300.0 | nM | 4.79 |
| CHEMBL3735192 | — | IC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL3735039 | — | IC50 | = | 31300.0 | nM | 4.50 |
| CHEMBL3736205 | — | IC50 | = | 62600.0 | nM | 4.20 |