Assay Detail
Binding
CHEMBL3737789
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Inhibition of recombinant human DPP4 expressed in Sf9 cells using Gly-Pro-AMC substrate after 30 mins by plate reader analysis
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity-relationship of amide and sulfonamide analogs of omarigliptin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 8.75 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3736137 | — | — | 1 | 9.52 |
| CHEMBL3735843 | — | — | 1 | 9.40 |
| CHEMBL3735865 | — | — | 1 | 9.15 |
| CHEMBL3734828 | — | — | 1 | 8.96 |
| CHEMBL3735461 | — | — | 1 | 8.89 |
| CHEMBL3736135 | — | — | 1 | 8.85 |
| CHEMBL2425070 | — | — | 1 | 8.85 |
| CHEMBL3736085 | — | — | 1 | 8.80 |
| CHEMBL3735329 | — | — | 1 | 8.80 |
| CHEMBL3736190 | — | — | 1 | 8.80 |
| CHEMBL3734964 | — | — | 1 | 8.80 |
| CHEMBL3735694 | — | — | 1 | 8.77 |
| CHEMBL3735917 | — | — | 1 | 8.77 |
| CHEMBL3735433 | — | — | 1 | 8.74 |
| CHEMBL3734999 | — | — | 1 | 8.74 |
| CHEMBL3735281 | — | — | 1 | 8.74 |
| CHEMBL3736423 | — | — | 1 | 8.72 |
| CHEMBL3736067 | — | — | 1 | 8.72 |
| CHEMBL3736188 | — | — | 1 | 8.64 |
| CHEMBL3736511 | — | — | 1 | 8.64 |
| CHEMBL2105762 | OMARIGLIPTIN | 4.0 | 1 | 8.59 |
| CHEMBL3645492 | — | — | 1 | 8.59 |
| CHEMBL3734769 | — | — | 1 | 8.49 |
| CHEMBL3735925 | — | — | 1 | 8.43 |
| CHEMBL3735129 | — | — | 1 | 8.37 |
| CHEMBL3735852 | — | — | 1 | 8.31 |
| CHEMBL3734912 | — | — | 1 | 8.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3736137 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL3735843 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL3735865 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL3734828 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL3735461 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL3736135 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL2425070 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL3736085 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL3735329 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL3736190 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL3734964 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL3735694 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL3735917 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL3735433 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL3734999 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL3735281 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL3736423 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL3736067 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL3736188 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL3736511 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL2105762 | OMARIGLIPTIN | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL3645492 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL3734769 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL3735925 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL3735129 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL3735852 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL3734912 | — | IC50 | = | 5.7 | nM | 8.24 |