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Assay Detail

CHEMBL3737860

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [35S]-MK-0499 from human ERG
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Publication

Discovery and Pharmacology of a Novel Class of Diacylglycerol Acyltransferase 2 Inhibitors.
Imbriglio JE, Shen DM, Liang R, Marby K, You M, Youm HW, Feng Z, London C, Xiong Y, Tata J, Verras A, Garcia-Calvo M, Song X, Addona GH, McLaren DG, He T, Murphy B, Metzger DE, Salituro G, Deckman D, Chen Q, Jin X, Stout SJ, Wang SP, Wilsie L, Palyha O, Han S, Hubbard BK, Previs SF, Pinto S, Taggart A.
J Med Chem (2015) 58 : 9345 -9353
PubMed 26561979 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 5.63 5.63

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3734797 1 5.63

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3734797 IC50 = 2340.0 nM 5.63