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Assay Detail

CHEMBL3738353

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human MAO-B expressed in baculovirus infected BT1 cells microsome fraction by fluorescence spectrometry
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Amine oxidase [flavin-containing] B (CHEMBL2039)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Monoamine oxidase inhibitory activities of heterocyclic chalcones.
Minders C, Petzer JP, Petzer A, Lourens AC.
Bioorg Med Chem Lett (2015) 25 : 5270 -5276
PubMed 26432037 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 6.43 7.17

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3735724 1 7.17
CHEMBL279390 LAZABEMIDE 2.0 1 7.04
CHEMBL3735123 1 6.94
CHEMBL3734767 1 6.88
CHEMBL2420790 1 6.76
CHEMBL3736131 1 6.73
CHEMBL2420785 1 6.70
CHEMBL2420787 1 6.56
CHEMBL3735467 1 6.48
CHEMBL2420693 1 6.31
CHEMBL2377627 1 6.28
CHEMBL2420694 1 6.21
CHEMBL3735584 1 6.09
CHEMBL3735202 1 6.08
CHEMBL3735739 1 5.85
CHEMBL2420793 1 5.68
CHEMBL3735451 1 5.49

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3735724 IC50 = 67.0 nM 7.17
CHEMBL279390 LAZABEMIDE IC50 = 91.0 nM 7.04
CHEMBL3735123 IC50 = 116.0 nM 6.94
CHEMBL3734767 IC50 = 133.0 nM 6.88
CHEMBL2420790 IC50 = 174.0 nM 6.76
CHEMBL3736131 IC50 = 185.0 nM 6.73
CHEMBL2420785 IC50 = 200.0 nM 6.70
CHEMBL2420787 IC50 = 275.0 nM 6.56
CHEMBL3735467 IC50 = 330.0 nM 6.48
CHEMBL2420693 IC50 = 490.0 nM 6.31
CHEMBL2377627 IC50 = 529.0 nM 6.28
CHEMBL2420694 IC50 = 616.0 nM 6.21
CHEMBL3735584 IC50 = 803.0 nM 6.09
CHEMBL3735202 IC50 = 830.0 nM 6.08
CHEMBL3735739 IC50 = 1400.0 nM 5.85
CHEMBL2420793 IC50 = 2100.0 nM 5.68
CHEMBL3735451 IC50 = 3270.0 nM 5.49