Assay Detail

CHEMBL3738356

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Binding

Inhibition of human MAO-B

ChEMBL ↗

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Target

Amine oxidase [flavin-containing] B (CHEMBL2039) ↗

Open DB target context

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Amine oxidase [flavin-containing] B (CHEMBL2039) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Amine oxidase [flavin-containing] B

CHEMBL2039

Anchored from Assay target.

Protein identity Amine oxidase [flavin-containing] B

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Amine oxidase [flavin-containing] B (CHEMBL2039) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Monoamine oxidase inhibitory activities of heterocyclic chalcones.

Minders C, Petzer JP, Petzer A, Lourens AC.
Bioorg Med Chem Lett (2015) 25 : 5270 -5276
PubMed 26432037 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.36	8.36

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL406861	—	—	1	8.36

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL406861	—	IC50	=	4.4	nM	8.36