Assay Detail
Binding
CHEMBL3738442
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Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Novel Multifunctional Ligands with μ/δ Opioid Agonist/Neurokinin-1 (NK1) Antagonist Activities for the Treatment of Pain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.44 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4299483 | — | — | 1 | 7.58 |
| CHEMBL4299390 | — | — | 1 | 7.57 |
| CHEMBL4299423 | — | — | 1 | 7.54 |
| CHEMBL438389 | — | — | 1 | 7.48 |
| CHEMBL4299415 | — | — | 1 | 7.47 |
| CHEMBL4299479 | — | — | 1 | 7.47 |
| CHEMBL4299402 | — | — | 1 | 7.41 |
| CHEMBL4299476 | — | — | 1 | 7.33 |
| CHEMBL4299371 | — | — | 1 | 7.32 |
| CHEMBL4299466 | — | — | 1 | 7.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4299483 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL4299390 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL4299423 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL438389 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL4299415 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL4299479 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL4299402 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL4299476 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL4299371 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL4299466 | — | Ki | = | 61.0 | nM | 7.21 |