Assay Detail
Functional
CHEMBL3739135
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Cytotoxicity against human KB cells after 72 hrs by SRB assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antiproliferativeactivity of new vinca alkaloids containing an α,β-unsaturated aromatic side chain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.31 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL501867 | VINCRISTINE SULFATE | 4.0 | 1 | 7.70 |
| CHEMBL376464 | — | — | 1 | 7.70 |
| CHEMBL3735611 | — | — | 1 | 7.52 |
| CHEMBL3734801 | — | — | 1 | 7.52 |
| CHEMBL3734923 | — | — | 1 | 7.22 |
| CHEMBL3735059 | — | — | 1 | 7.10 |
| CHEMBL3735179 | — | — | 1 | 6.55 |
| CHEMBL3736019 | — | — | 1 | 6.19 |
| CHEMBL3736373 | — | — | 1 | 6.19 |
| CHEMBL3734884 | — | — | 1 | 5.78 |
| CHEMBL123 | ELLIPTECINE | — | 1 | 5.78 |
| CHEMBL3736431 | — | — | 1 | 5.77 |
| CHEMBL509507 | — | — | 1 | 5.69 |
| CHEMBL3735619 | — | — | 1 | 5.38 |
| CHEMBL3735939 | — | — | 1 | 5.21 |
| CHEMBL3735620 | — | — | 1 | 5.04 |
| CHEMBL3735398 | — | — | 1 | 4.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL501867 | VINCRISTINE SULFATE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL376464 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3735611 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3734801 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3734923 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3735059 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3735179 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL3736019 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL3736373 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL3734884 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL123 | ELLIPTECINE | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL3736431 | — | IC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL509507 | — | IC50 | = | 2060.0 | nM | 5.69 |
| CHEMBL3735619 | — | IC50 | = | 4160.0 | nM | 5.38 |
| CHEMBL3735939 | — | IC50 | = | 6120.0 | nM | 5.21 |
| CHEMBL3735620 | — | IC50 | = | 9110.0 | nM | 5.04 |
| CHEMBL3735398 | — | IC50 | = | 11500.0 | nM | 4.94 |