Assay Detail
Binding
CHEMBL3739215
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological activity of 4-[(benzimidazol-1-yl)methyl]biphenyl-2-sulphonamides as dual angiotensin II and endothelin A receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 7.38 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12233 | — | — | 1 | 8.89 |
| CHEMBL12106 | — | — | 1 | 8.70 |
| CHEMBL12013 | — | — | 1 | 8.70 |
| CHEMBL11706 | BMS-248360 | — | 1 | 8.22 |
| CHEMBL3736242 | — | — | 1 | 8.15 |
| CHEMBL275545 | — | — | 1 | 8.10 |
| CHEMBL3735574 | — | — | 1 | 8.10 |
| CHEMBL3734968 | — | — | 1 | 7.89 |
| CHEMBL3735155 | — | — | 1 | 7.80 |
| CHEMBL12333 | — | — | 1 | 7.68 |
| CHEMBL417429 | — | — | 1 | 7.62 |
| CHEMBL3735931 | — | — | 1 | 7.55 |
| CHEMBL11528 | — | — | 1 | 7.52 |
| CHEMBL3736037 | — | — | 1 | 7.51 |
| CHEMBL3734870 | — | — | 1 | 7.43 |
| CHEMBL3736248 | — | — | 1 | 7.38 |
| CHEMBL3735236 | — | — | 1 | 7.33 |
| CHEMBL3736262 | — | — | 1 | 7.30 |
| CHEMBL3735151 | — | — | 1 | 7.25 |
| CHEMBL3736414 | — | — | 1 | 7.12 |
| CHEMBL3734835 | — | — | 1 | 7.09 |
| CHEMBL3734955 | — | — | 1 | 7.04 |
| CHEMBL3735302 | — | — | 1 | 7.03 |
| CHEMBL3736507 | — | — | 1 | 7.02 |
| CHEMBL3735265 | — | — | 1 | 6.82 |
| CHEMBL3734829 | — | — | 1 | 6.80 |
| CHEMBL3735036 | — | — | 1 | 6.70 |
| CHEMBL3734849 | — | — | 1 | 6.66 |
| CHEMBL3736310 | — | — | 1 | 6.47 |
| CHEMBL3735797 | — | — | 1 | 6.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12233 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL12106 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL12013 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL11706 | BMS-248360 | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3736242 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL275545 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3735574 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3734968 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3735155 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL12333 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL417429 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3735931 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL11528 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3736037 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3734870 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL3736248 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL3735236 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL3736262 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3735151 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL3736414 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL3734835 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL3734955 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL3735302 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL3736507 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL3735265 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL3734829 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3735036 | — | IC50 | = | 201.0 | nM | 6.70 |
| CHEMBL3734849 | — | IC50 | = | 217.0 | nM | 6.66 |
| CHEMBL3736310 | — | IC50 | = | 341.0 | nM | 6.47 |
| CHEMBL3735797 | — | IC50 | = | 373.0 | nM | 6.43 |
| CHEMBL3736225 | — | IC50 | = | 385.0 | nM | 6.42 |
| CHEMBL3735300 | — | IC50 | = | 419.0 | nM | 6.38 |
| CHEMBL3735311 | — | IC50 | = | 465.0 | nM | 6.33 |