Assay Detail
Binding
CHEMBL3742609
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Displacement of [3H]-sulpiride from human dopamine D3 receptor expressed in HEK293 cells after 150 mins by liquid scintillation counting
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of bitopic arylpiperazinephenyl-1,2,4-oxadiazoles as preferential dopamine D3 receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.40 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3739820 | — | — | 1 | 6.57 |
| CHEMBL3740498 | — | — | 1 | 6.54 |
| CHEMBL339960 | — | — | 1 | 6.39 |
| CHEMBL3740360 | — | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3739820 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL3740498 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL339960 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL3740360 | — | Ki | = | 810.0 | nM | 6.09 |