Assay Detail
Binding
CHEMBL3743101
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Inhibition of MMP13 (unknown origin) using Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate after 3 mins by fluorimetric assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Evaluation of the anti-inflammatory/chondroprotective activity of aldose reductase inhibitors in human chondrocyte cultures
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.35 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1645391 | — | — | 1 | 6.19 |
| CHEMBL184768 | — | — | 1 | 5.80 |
| CHEMBL1645387 | — | — | 1 | 5.42 |
| CHEMBL1645389 | — | — | 1 | 5.40 |
| CHEMBL1172417 | — | — | 1 | 5.33 |
| CHEMBL1645390 | — | — | 1 | 5.23 |
| CHEMBL185623 | — | — | 1 | 5.16 |
| CHEMBL161669 | — | — | 1 | 4.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1645391 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL184768 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL1645387 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL1645389 | — | IC50 | = | 3990.0 | nM | 5.40 |
| CHEMBL1172417 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL1645390 | — | IC50 | = | 5890.0 | nM | 5.23 |
| CHEMBL185623 | — | IC50 | = | 6970.0 | nM | 5.16 |
| CHEMBL161669 | — | IC50 | = | 55270.0 | nM | 4.26 |