Assay Detail
Binding
CHEMBL3743871
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to GST-PPAR-beta/delta LBP (unknown origin) after 3 hrs by TR-FRET assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor delta (CHEMBL3979) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis of 5-trifluoromethyl-2-sulfonylpyridine PPARβ/δ antagonists: Effects on the affinity and selectivity towards PPARβ/δ.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.52 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2030550 | — | — | 1 | 7.40 |
| CHEMBL598608 | — | — | 1 | 6.63 |
| CHEMBL3416764 | — | — | 1 | 6.55 |
| CHEMBL3740264 | — | — | 1 | 6.50 |
| CHEMBL3740369 | — | — | 1 | 6.22 |
| CHEMBL3740002 | — | — | 1 | 5.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2030550 | — | IC50 | = | 40.1 | nM | 7.40 |
| CHEMBL598608 | — | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL3416764 | — | IC50 | = | 284.0 | nM | 6.55 |
| CHEMBL3740264 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL3740369 | — | IC50 | = | 598.0 | nM | 6.22 |
| CHEMBL3740002 | — | IC50 | = | 1431.0 | nM | 5.84 |