Assay Detail
Binding
CHEMBL3743972
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human plasma plasmin using pyroGlu-Pro-Arg-pNA-HCl as substrate measured for 5 mins by spectrophotometric assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and SAR of Novel and Selective Inhibitors of Urokinase Plasminogen Activator (uPA) with an Imidazo[1,2-a]pyridine Scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.14 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1945236 | — | — | 1 | 6.47 |
| CHEMBL87563 | GABEXATE | 3.0 | 1 | 5.81 |
| CHEMBL3740183 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1945236 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL87563 | GABEXATE | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL3740183 | — | IC50 | > | 100000.0 | nM | - |