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Assay Detail

CHEMBL3744022

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Anticancer activity against human HeLa cells assessed as cell viability after 48 hrs by MTT assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HeLa
Confidence 1 — Organism
Curated By Autocuration

Target

HeLa (CHEMBL399)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis, biological activity evaluation and molecular docking studies of novel coumarin substituted thiazolyl-3-aryl-pyrazole-4-carbaldehydes.
Vaarla K, Kesharwani RK, Santosh K, Vedula RR, Kotamraju S, Toopurani MK.
Bioorg Med Chem Lett (2015) 25 : 5797 -5803
PubMed 26542964 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 4.90 5.41

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL53463 DOXORUBICIN 4.0 1 5.41
CHEMBL3742224 1 5.24
CHEMBL3741757 1 5.20
CHEMBL3740695 1 5.02
CHEMBL3739672 1 5.02
CHEMBL3741819 1 4.99
CHEMBL3742302 1 4.96
CHEMBL3742383 1 4.89
CHEMBL3740883 1 4.88
CHEMBL3740871 1 4.86
CHEMBL3740335 1 4.86
CHEMBL3740902 1 4.85
CHEMBL3739596 1 4.55
CHEMBL3740529 1 4.43
CHEMBL3740860 1 4.38
CHEMBL3739579 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL53463 DOXORUBICIN IC50 = 3920.0 nM 5.41
CHEMBL3742224 IC50 = 5750.0 nM 5.24
CHEMBL3741757 IC50 = 6250.0 nM 5.20
CHEMBL3740695 IC50 = 9510.0 nM 5.02
CHEMBL3739672 IC50 = 9460.0 nM 5.02
CHEMBL3741819 IC50 = 10290.0 nM 4.99
CHEMBL3742302 IC50 = 11020.0 nM 4.96
CHEMBL3742383 IC50 = 12820.0 nM 4.89
CHEMBL3740883 IC50 = 13110.0 nM 4.88
CHEMBL3740871 IC50 = 13750.0 nM 4.86
CHEMBL3740335 IC50 = 13690.0 nM 4.86
CHEMBL3740902 IC50 = 14130.0 nM 4.85
CHEMBL3739596 IC50 = 28190.0 nM 4.55
CHEMBL3740529 IC50 = 37360.0 nM 4.43
CHEMBL3740860 IC50 = 41890.0 nM 4.38
CHEMBL3739579 IC50 > 100000.0 nM -