Assay Detail
Binding
CHEMBL3744281
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Inhibition of HDAC1 (unknown origin) by fluorimetric assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Cross metathesis with hydroxamate and benzamide BOC-protected alkenes to access HDAC inhibitors and their biological evaluation highlighted intrinsic activity of BOC-protected dihydroxamates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.23 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.46 |
| CHEMBL320497 | SUBEROHYDROXAMIC ACID | — | 1 | 5.20 |
| CHEMBL235191 | TACEDINALINE | 3.0 | 1 | 4.74 |
| CHEMBL3739529 | — | — | 1 | 4.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL320497 | SUBEROHYDROXAMIC ACID | IC50 | = | 6310.0 | nM | 5.20 |
| CHEMBL235191 | TACEDINALINE | IC50 | = | 18220.0 | nM | 4.74 |
| CHEMBL3739529 | — | IC50 | = | 30560.0 | nM | 4.51 |