Assay Detail
Binding
CHEMBL3744284
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Inhibition of HDAC6 (unknown origin) by fluorimetric assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Cross metathesis with hydroxamate and benzamide BOC-protected alkenes to access HDAC inhibitors and their biological evaluation highlighted intrinsic activity of BOC-protected dihydroxamates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.15 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.30 |
| CHEMBL320497 | SUBEROHYDROXAMIC ACID | — | 1 | 5.69 |
| CHEMBL3739529 | — | — | 1 | 5.47 |
| CHEMBL235191 | TACEDINALINE | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL320497 | SUBEROHYDROXAMIC ACID | IC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL3739529 | — | IC50 | = | 3390.0 | nM | 5.47 |
| CHEMBL235191 | TACEDINALINE | IC50 | > | 100000.0 | nM | - |