Assay Detail
Binding
CHEMBL3744622
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [33P]S1P from S1P1 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB method
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of A-971432, An Orally Bioavailable Selective Sphingosine-1-Phosphate Receptor 5 (S1P5) Agonist for the Potential Treatment of Neurodegenerative Disorders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 6.27 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3741743 | — | — | 1 | 8.70 |
| CHEMBL3739878 | — | — | 1 | 8.70 |
| CHEMBL3739440 | — | — | 1 | 8.30 |
| CHEMBL3740062 | — | — | 1 | 7.75 |
| CHEMBL3741496 | — | — | 1 | 7.32 |
| CHEMBL3741364 | — | — | 1 | 6.92 |
| CHEMBL1973936 | — | — | 1 | 6.66 |
| CHEMBL3741022 | — | — | 1 | 6.66 |
| CHEMBL3741589 | — | — | 1 | 6.44 |
| CHEMBL3740359 | — | — | 1 | 6.18 |
| CHEMBL1968499 | — | — | 1 | 6.08 |
| CHEMBL1971132 | — | — | 1 | 5.97 |
| CHEMBL3740060 | — | — | 1 | 5.93 |
| CHEMBL3742245 | — | — | 1 | 5.75 |
| CHEMBL3742304 | — | — | 1 | 5.52 |
| CHEMBL3740090 | — | — | 1 | 5.46 |
| CHEMBL3740494 | — | — | 1 | 5.41 |
| CHEMBL3742033 | — | — | 1 | 5.38 |
| CHEMBL1987998 | — | — | 1 | 5.37 |
| CHEMBL3742345 | — | — | 1 | 5.36 |
| CHEMBL3740768 | — | — | 1 | 5.28 |
| CHEMBL3741222 | — | — | 1 | 5.21 |
| CHEMBL3742384 | — | — | 1 | 5.14 |
| CHEMBL3741338 | — | — | 1 | 5.01 |
| CHEMBL3740188 | — | — | 1 | - |
| CHEMBL3739977 | — | — | 1 | - |
| CHEMBL3740355 | — | — | 1 | - |
| CHEMBL3740219 | — | — | 1 | - |
| CHEMBL3742100 | — | — | 1 | - |
| CHEMBL3741414 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3741743 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3739878 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3739440 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3740062 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3741496 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL3741364 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1973936 | — | IC50 | = | 221.0 | nM | 6.66 |
| CHEMBL3741022 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL3741589 | — | IC50 | = | 362.0 | nM | 6.44 |
| CHEMBL3740359 | — | IC50 | = | 656.0 | nM | 6.18 |
| CHEMBL1968499 | — | IC50 | = | 835.0 | nM | 6.08 |
| CHEMBL1971132 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL3740060 | — | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL3742245 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL3742304 | — | IC50 | = | 3030.0 | nM | 5.52 |
| CHEMBL3740090 | — | IC50 | = | 3460.0 | nM | 5.46 |
| CHEMBL3740494 | — | IC50 | = | 3870.0 | nM | 5.41 |
| CHEMBL3742033 | — | IC50 | = | 4170.0 | nM | 5.38 |
| CHEMBL1987998 | — | IC50 | = | 4230.0 | nM | 5.37 |
| CHEMBL3742345 | — | IC50 | = | 4410.0 | nM | 5.36 |
| CHEMBL3740768 | — | IC50 | = | 5260.0 | nM | 5.28 |
| CHEMBL3741222 | — | IC50 | = | 6230.0 | nM | 5.21 |
| CHEMBL3742384 | — | IC50 | = | 7210.0 | nM | 5.14 |
| CHEMBL3741338 | — | IC50 | = | 9810.0 | nM | 5.01 |
| CHEMBL3740188 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3739977 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3740355 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3740219 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3742100 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3741414 | — | IC50 | < | 1.0 | nM | - |