Assay Detail
Binding
CHEMBL3744882
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of West Nile virus NS2B-NS3 protease using 2-Abz-Gly-Leu-Lys-Arg-Gly-Gly-(3-NO3)-Tyr-NH2 as substrate preincubated with protein for 15 mins followed by substrate addition measured for 15 mins by FRET assay
88
Total Activities
85
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | West Nile virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of Nanomolar Dengue and West Nile Virus Protease Inhibitors Containing a 4-Benzyloxyphenylglycine Residue.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 85 | 6.38 | 7.30 |
| Ki | 3 | 6.90 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3740727 | — | — | 2 | 7.41 |
| CHEMBL3740757 | — | — | 1 | 7.10 |
| CHEMBL3739493 | — | — | 2 | 7.03 |
| CHEMBL3739872 | — | — | 1 | 6.82 |
| CHEMBL3739737 | — | — | 1 | 6.80 |
| CHEMBL3740386 | — | — | 1 | 6.78 |
| CHEMBL3740686 | — | — | 1 | 6.67 |
| CHEMBL3740524 | — | — | 1 | 6.67 |
| CHEMBL3739978 | — | — | 1 | 6.66 |
| CHEMBL3740133 | — | — | 1 | 6.65 |
| CHEMBL3740745 | — | — | 1 | 6.64 |
| CHEMBL3741832 | — | — | 1 | 6.56 |
| CHEMBL3740340 | — | — | 1 | 6.53 |
| CHEMBL3741786 | — | — | 1 | 6.51 |
| CHEMBL3742054 | — | — | 1 | 6.49 |
| CHEMBL3741557 | — | — | 1 | 6.46 |
| CHEMBL3739794 | — | — | 1 | 6.46 |
| CHEMBL3741755 | — | — | 1 | 6.44 |
| CHEMBL3739504 | — | — | 1 | 6.44 |
| CHEMBL3740603 | — | — | 1 | 6.43 |
| CHEMBL3740808 | — | — | 1 | 6.43 |
| CHEMBL3740465 | — | — | 1 | 6.40 |
| CHEMBL3742195 | — | — | 1 | 6.39 |
| CHEMBL3742115 | — | — | 1 | 6.37 |
| CHEMBL3741232 | — | — | 1 | 6.36 |
| CHEMBL3741209 | — | — | 1 | 6.36 |
| CHEMBL3740968 | — | — | 1 | 6.34 |
| CHEMBL3739705 | — | — | 1 | 6.31 |
| CHEMBL3741143 | — | — | 1 | 6.31 |
| CHEMBL3740226 | — | — | 1 | 6.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3740727 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL3740727 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3740757 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL3739493 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL3739493 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL3739872 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3739737 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL3740386 | — | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL3740524 | — | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL3740686 | — | IC50 | = | 216.0 | nM | 6.67 |
| CHEMBL3739978 | — | IC50 | = | 221.0 | nM | 6.66 |
| CHEMBL3740133 | — | IC50 | = | 224.0 | nM | 6.65 |
| CHEMBL3740745 | — | IC50 | = | 231.0 | nM | 6.64 |
| CHEMBL3741832 | — | IC50 | = | 273.0 | nM | 6.56 |
| CHEMBL3740340 | — | IC50 | = | 296.0 | nM | 6.53 |
| CHEMBL3741786 | — | IC50 | = | 308.0 | nM | 6.51 |
| CHEMBL3742054 | — | IC50 | = | 321.0 | nM | 6.49 |
| CHEMBL3741557 | — | IC50 | = | 349.0 | nM | 6.46 |
| CHEMBL3739794 | — | IC50 | = | 348.0 | nM | 6.46 |
| CHEMBL3739504 | — | IC50 | = | 365.0 | nM | 6.44 |
| CHEMBL3741755 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL3740808 | — | IC50 | = | 368.0 | nM | 6.43 |
| CHEMBL3740603 | — | IC50 | = | 371.0 | nM | 6.43 |
| CHEMBL3740465 | — | IC50 | = | 398.0 | nM | 6.40 |
| CHEMBL3742195 | — | IC50 | = | 406.0 | nM | 6.39 |
| CHEMBL3742115 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL3741209 | — | IC50 | = | 434.0 | nM | 6.36 |
| CHEMBL3741232 | — | IC50 | = | 434.0 | nM | 6.36 |
| CHEMBL3740968 | — | IC50 | = | 457.0 | nM | 6.34 |
| CHEMBL3741227 | — | IC50 | = | 486.0 | nM | 6.31 |
| CHEMBL3739705 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL3741143 | — | IC50 | = | 487.0 | nM | 6.31 |
| CHEMBL3740226 | — | IC50 | = | 493.0 | nM | 6.31 |
| CHEMBL3739439 | — | IC50 | = | 508.0 | nM | 6.29 |
| CHEMBL3739545 | — | IC50 | = | 507.0 | nM | 6.29 |
| CHEMBL3741422 | — | Ki | = | 536.0 | nM | 6.27 |
| CHEMBL3741023 | — | IC50 | = | 561.0 | nM | 6.25 |
| CHEMBL3741713 | — | IC50 | = | 557.0 | nM | 6.25 |
| CHEMBL3740868 | — | IC50 | = | 604.0 | nM | 6.22 |
| CHEMBL3741958 | — | IC50 | = | 615.0 | nM | 6.21 |
| CHEMBL3741422 | — | IC50 | = | 728.0 | nM | 6.14 |
| CHEMBL3741034 | — | IC50 | = | 785.0 | nM | 6.11 |
| CHEMBL3739995 | — | IC50 | = | 821.0 | nM | 6.09 |
| CHEMBL3739908 | — | IC50 | = | 804.0 | nM | 6.09 |
| CHEMBL3741395 | — | IC50 | = | 1294.0 | nM | 5.89 |
| CHEMBL3741308 | — | IC50 | = | 1661.0 | nM | 5.78 |
| CHEMBL3740277 | — | IC50 | = | 3780.0 | nM | 5.42 |
| CHEMBL3739888 | — | IC50 | = | 15920.0 | nM | 4.80 |
| CHEMBL3740600 | — | IC50 | - | — | - | |
| CHEMBL3740845 | — | IC50 | - | — | - |