Assay Detail
Binding
CHEMBL3744883
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Dengue virus serotype-2 NS2B-NS3 protease using 2-Abz-Nle-Lys-Arg-Arg-Ser-(3-NO2)-Tyr-NH2 as substrate preincubated with protein for 15 mins followed by substrate addition measured for 15 mins by FRET assay
88
Total Activities
85
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | dengue virus type 2 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of Nanomolar Dengue and West Nile Virus Protease Inhibitors Containing a 4-Benzyloxyphenylglycine Residue.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 85 | 6.60 | 7.75 |
| Ki | 3 | 7.38 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3740727 | — | — | 2 | 7.92 |
| CHEMBL3739493 | — | — | 2 | 7.72 |
| CHEMBL3741832 | — | — | 1 | 7.33 |
| CHEMBL3740386 | — | — | 1 | 7.30 |
| CHEMBL3740686 | — | — | 1 | 7.21 |
| CHEMBL3740745 | — | — | 1 | 7.17 |
| CHEMBL3740133 | — | — | 1 | 7.16 |
| CHEMBL3739872 | — | — | 1 | 7.15 |
| CHEMBL3740757 | — | — | 1 | 7.10 |
| CHEMBL3739737 | — | — | 1 | 7.00 |
| CHEMBL3740340 | — | — | 1 | 6.96 |
| CHEMBL3740603 | — | — | 1 | 6.96 |
| CHEMBL3739995 | — | — | 1 | 6.92 |
| CHEMBL3739622 | — | — | 1 | 6.92 |
| CHEMBL3740519 | — | — | 1 | 6.89 |
| CHEMBL3739978 | — | — | 1 | 6.89 |
| CHEMBL3741227 | — | — | 1 | 6.84 |
| CHEMBL3741143 | — | — | 1 | 6.83 |
| CHEMBL3739908 | — | — | 1 | 6.83 |
| CHEMBL3740226 | — | — | 1 | 6.82 |
| CHEMBL3741034 | — | — | 1 | 6.80 |
| CHEMBL3739888 | — | — | 1 | 6.80 |
| CHEMBL3741620 | — | — | 1 | 6.79 |
| CHEMBL3741198 | — | — | 1 | 6.77 |
| CHEMBL3740285 | — | — | 1 | 6.76 |
| CHEMBL3739794 | — | — | 1 | 6.76 |
| CHEMBL3741958 | — | — | 1 | 6.75 |
| CHEMBL3741713 | — | — | 1 | 6.75 |
| CHEMBL3739705 | — | — | 1 | 6.75 |
| CHEMBL3740968 | — | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3740727 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL3740727 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3739493 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL3739493 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3741832 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL3740386 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3740686 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL3740745 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL3740133 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL3739872 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL3740757 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL3739737 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL3740340 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL3740603 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL3739995 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3739622 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL3739978 | — | IC50 | = | 129.0 | nM | 6.89 |
| CHEMBL3740519 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3741227 | — | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL3741143 | — | IC50 | = | 148.0 | nM | 6.83 |
| CHEMBL3739908 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL3740226 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL3739888 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL3741034 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL3741620 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL3741198 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3739794 | — | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL3740285 | — | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL3739705 | — | IC50 | = | 179.0 | nM | 6.75 |
| CHEMBL3740968 | — | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL3741713 | — | IC50 | = | 176.0 | nM | 6.75 |
| CHEMBL3741958 | — | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL3740444 | — | IC50 | = | 181.0 | nM | 6.74 |
| CHEMBL3741849 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL3739438 | — | IC50 | = | 182.0 | nM | 6.74 |
| CHEMBL3742054 | — | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL3742057 | — | IC50 | = | 192.0 | nM | 6.72 |
| CHEMBL3741725 | — | IC50 | = | 194.0 | nM | 6.71 |
| CHEMBL3740845 | — | IC50 | = | 197.0 | nM | 6.71 |
| CHEMBL3740985 | — | IC50 | = | 194.0 | nM | 6.71 |
| CHEMBL3741557 | — | IC50 | = | 196.0 | nM | 6.71 |
| CHEMBL3740868 | — | IC50 | = | 199.0 | nM | 6.70 |
| CHEMBL3740600 | — | IC50 | = | 203.0 | nM | 6.69 |
| CHEMBL3739504 | — | IC50 | = | 215.0 | nM | 6.67 |
| CHEMBL3741786 | — | IC50 | = | 236.0 | nM | 6.63 |
| CHEMBL3741633 | — | IC50 | = | 232.0 | nM | 6.63 |
| CHEMBL3742397 | — | IC50 | = | 243.0 | nM | 6.61 |
| CHEMBL3741714 | — | IC50 | = | 262.0 | nM | 6.58 |
| CHEMBL3741232 | — | IC50 | = | 301.0 | nM | 6.52 |
| CHEMBL3740465 | — | IC50 | = | 304.0 | nM | 6.52 |