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Assay Detail

CHEMBL3745054

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as growth inhibition after 48 hrs by SYBR Green 1 staining-based fluorescence assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

2-Pyridylquinoloneantimalarials with improved antimalarial activity and physicochemical properties
Charoensutthivarakul S, David Hong W, Leung SC, Gibbons PD, Bedingfield PTP, Nixon GL, Lawrenson AS, Berry NG, Ward SA, Biagini GA, O'Neill PM
Medchemcomm (2015) 6 : 1252 -1259
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 7.19 7.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3740357 1 7.92
CHEMBL3741741 1 7.92
CHEMBL3740339 1 7.85
CHEMBL3739664 1 7.75
CHEMBL3742369 1 7.68
CHEMBL3741501 1 7.40
CHEMBL3739911 1 7.39
CHEMBL2030298 1 7.27
CHEMBL3741254 1 7.16
CHEMBL3740894 1 6.83
CHEMBL3740495 1 6.82
CHEMBL3739483 1 6.70
CHEMBL3741180 1 6.70
CHEMBL2030317 1 6.70
CHEMBL2030316 1 6.49
CHEMBL3739989 1 6.41
CHEMBL3740532 1 -
CHEMBL3740623 1 -
CHEMBL2030308 1 -
CHEMBL2030318 1 -
CHEMBL2030301 1 -
CHEMBL2030299 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3740357 IC50 = 12.0 nM 7.92
CHEMBL3741741 IC50 = 12.0 nM 7.92
CHEMBL3740339 IC50 = 14.0 nM 7.85
CHEMBL3739664 IC50 = 18.0 nM 7.75
CHEMBL3742369 IC50 = 21.0 nM 7.68
CHEMBL3741501 IC50 = 40.0 nM 7.40
CHEMBL3739911 IC50 = 41.0 nM 7.39
CHEMBL2030298 IC50 = 54.0 nM 7.27
CHEMBL3741254 IC50 = 70.0 nM 7.16
CHEMBL3740894 IC50 = 149.0 nM 6.83
CHEMBL3740495 IC50 = 150.0 nM 6.82
CHEMBL3739483 IC50 = 200.0 nM 6.70
CHEMBL3741180 IC50 = 200.0 nM 6.70
CHEMBL2030317 IC50 = 202.0 nM 6.70
CHEMBL2030316 IC50 = 326.0 nM 6.49
CHEMBL3739989 IC50 = 390.0 nM 6.41
CHEMBL3740532 IC50 > 1000.0 nM -
CHEMBL3740623 IC50 > 1000.0 nM -
CHEMBL2030308 IC50 > 1000.0 nM -
CHEMBL2030318 IC50 > 1000.0 nM -
CHEMBL2030301 IC50 > 1000.0 nM -
CHEMBL2030299 IC50 > 1000.0 nM -