Assay Detail
Functional
CHEMBL3745056
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Antimalarial activity against drug resistant Plasmodium falciparum TM90C2B infected in human erythrocytes assessed as growth inhibition after 48 hrs by SYBR Green 1 staining-based fluorescence assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
2-Pyridylquinoloneantimalarials with improved antimalarial activity and physicochemical properties
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.19 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3740357 | — | — | 1 | 8.15 |
| CHEMBL3741741 | — | — | 1 | 8.14 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.84 |
| CHEMBL2030298 | — | — | 1 | 6.81 |
| CHEMBL1450 | ATOVAQUONE | 4.0 | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3740357 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3741741 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 14.5 | nM | 7.84 |
| CHEMBL2030298 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL1450 | ATOVAQUONE | IC50 | = | 9908.0 | nM | 5.00 |