Assay Detail
Functional
CHEMBL3745238
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of a Highly Potent D2/D3 Agonist and a Partial Agonist from Structure-Activity Relationship Study of N(6)-(2-(4-(1H-Indol-5-yl)piperazin-1-yl)ethyl)-N(6)-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine Analogues: Implication in the Treatment of Parkinson's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 8.31 | 9.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3742140 | — | — | 1 | 9.08 |
| CHEMBL3740041 | — | — | 1 | 8.85 |
| CHEMBL3740286 | — | — | 1 | 8.41 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 8.27 |
| CHEMBL3740778 | — | — | 1 | 7.96 |
| CHEMBL7549 | PRECLAMOL | 2.0 | 1 | 7.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3742140 | — | EC50 | = | 0.84 | nM | 9.08 |
| CHEMBL3740041 | — | EC50 | = | 1.41 | nM | 8.85 |
| CHEMBL3740286 | — | EC50 | = | 3.93 | nM | 8.41 |
| CHEMBL59 | DOPAMINE | EC50 | = | 5.34 | nM | 8.27 |
| CHEMBL3740778 | — | EC50 | = | 10.9 | nM | 7.96 |
| CHEMBL7549 | PRECLAMOL | EC50 | = | 51.9 | nM | 7.29 |