Assay Detail
Binding
CHEMBL3745316
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Inhibition of human MAO-B using p-tyramine as substrate assessed as production of H2O2 from p-tyramine incubated for 15 mins by Amplex Red MAO assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Chromanones: selective and reversible monoamine oxidase B inhibitors with nanomolar potency
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 6.79 | 8.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1682819 | — | — | 1 | 8.06 |
| CHEMBL3741461 | — | — | 1 | 7.99 |
| CHEMBL3741156 | — | — | 1 | 7.67 |
| CHEMBL3739707 | — | — | 1 | 7.52 |
| CHEMBL3741418 | — | — | 1 | 7.48 |
| CHEMBL1682815 | — | — | 1 | 7.45 |
| CHEMBL3739471 | — | — | 1 | 7.36 |
| CHEMBL3741888 | — | — | 1 | 7.34 |
| CHEMBL3742022 | — | — | 1 | 7.33 |
| CHEMBL1682818 | — | — | 1 | 7.29 |
| CHEMBL1682816 | — | — | 1 | 7.28 |
| CHEMBL3739629 | — | — | 1 | 7.28 |
| CHEMBL3742390 | — | — | 1 | 7.26 |
| CHEMBL1348198 | — | — | 1 | 7.24 |
| CHEMBL3742068 | — | — | 1 | 7.23 |
| CHEMBL3741949 | — | — | 1 | 7.18 |
| CHEMBL3741889 | — | — | 1 | 7.16 |
| CHEMBL3740665 | — | — | 1 | 7.16 |
| CHEMBL3741822 | — | — | 1 | 7.04 |
| CHEMBL3741067 | — | — | 1 | 7.01 |
| CHEMBL3740583 | — | — | 1 | 7.01 |
| CHEMBL3741989 | — | — | 1 | 6.95 |
| CHEMBL673 | PARGYLINE | 4.0 | 1 | 6.70 |
| CHEMBL3739905 | — | — | 1 | 6.60 |
| CHEMBL3741782 | — | — | 1 | 5.67 |
| CHEMBL92401 | IPRONIAZID | 2.0 | 1 | 5.11 |
| CHEMBL3740100 | — | — | 1 | 4.82 |
| CHEMBL3740394 | — | — | 1 | 4.69 |
| CHEMBL3739915 | — | — | 1 | 4.67 |
| CHEMBL3741078 | — | — | 1 | 4.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1682819 | — | IC50 | = | 8.62 | nM | 8.06 |
| CHEMBL3741461 | — | IC50 | = | 10.26 | nM | 7.99 |
| CHEMBL3741156 | — | IC50 | = | 21.56 | nM | 7.67 |
| CHEMBL3739707 | — | IC50 | = | 30.27 | nM | 7.52 |
| CHEMBL3741418 | — | IC50 | = | 33.45 | nM | 7.48 |
| CHEMBL1682815 | — | IC50 | = | 35.26 | nM | 7.45 |
| CHEMBL3739471 | — | IC50 | = | 44.18 | nM | 7.36 |
| CHEMBL3741888 | — | IC50 | = | 45.36 | nM | 7.34 |
| CHEMBL3742022 | — | IC50 | = | 47.28 | nM | 7.33 |
| CHEMBL1682818 | — | IC50 | = | 51.37 | nM | 7.29 |
| CHEMBL1682816 | — | IC50 | = | 52.65 | nM | 7.28 |
| CHEMBL3739629 | — | IC50 | = | 52.23 | nM | 7.28 |
| CHEMBL3742390 | — | IC50 | = | 55.37 | nM | 7.26 |
| CHEMBL1348198 | — | IC50 | = | 57.37 | nM | 7.24 |
| CHEMBL3742068 | — | IC50 | = | 58.82 | nM | 7.23 |
| CHEMBL3741949 | — | IC50 | = | 65.48 | nM | 7.18 |
| CHEMBL3741889 | — | IC50 | = | 68.78 | nM | 7.16 |
| CHEMBL3740665 | — | IC50 | = | 69.51 | nM | 7.16 |
| CHEMBL3741822 | — | IC50 | = | 91.29 | nM | 7.04 |
| CHEMBL3741067 | — | IC50 | = | 97.47 | nM | 7.01 |
| CHEMBL3740583 | — | IC50 | = | 98.32 | nM | 7.01 |
| CHEMBL3741989 | — | IC50 | = | 113.21 | nM | 6.95 |
| CHEMBL673 | PARGYLINE | IC50 | = | 198.5 | nM | 6.70 |
| CHEMBL3739905 | — | IC50 | = | 251.14 | nM | 6.60 |
| CHEMBL3741782 | — | IC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL92401 | IPRONIAZID | IC50 | = | 7690.0 | nM | 5.11 |
| CHEMBL3740100 | — | IC50 | = | 15210.0 | nM | 4.82 |
| CHEMBL3740394 | — | IC50 | = | 20510.0 | nM | 4.69 |
| CHEMBL3739915 | — | IC50 | = | 21450.0 | nM | 4.67 |
| CHEMBL3741078 | — | IC50 | = | 78860.0 | nM | 4.10 |