Assay Detail
Binding
CHEMBL3745476
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Inhibition of Staphylococcus aureus Gyrase B ATPase activity by fluorescence analysis
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Indazole Derivatives as a Novel Class of Bacterial Gyrase B Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 7.63 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3741798 | — | — | 1 | 8.10 |
| CHEMBL3739786 | — | — | 1 | 8.05 |
| CHEMBL3741350 | — | — | 1 | 8.05 |
| CHEMBL3741270 | — | — | 1 | 8.00 |
| CHEMBL3739453 | — | — | 1 | 7.96 |
| CHEMBL3739840 | — | — | 1 | 7.96 |
| CHEMBL3742199 | — | — | 1 | 7.96 |
| CHEMBL3741475 | — | — | 1 | 7.92 |
| CHEMBL3741905 | — | — | 1 | 7.89 |
| CHEMBL3739628 | — | — | 1 | 7.89 |
| CHEMBL3741327 | — | — | 1 | 7.85 |
| CHEMBL3739780 | — | — | 1 | 7.82 |
| CHEMBL3739580 | — | — | 1 | 7.82 |
| CHEMBL3739684 | — | — | 1 | 7.70 |
| CHEMBL3741416 | — | — | 1 | 7.60 |
| CHEMBL3740656 | — | — | 1 | 7.54 |
| CHEMBL3742250 | — | — | 1 | 7.31 |
| CHEMBL3741742 | — | — | 1 | 7.28 |
| CHEMBL3741635 | — | — | 1 | 6.78 |
| CHEMBL3739906 | — | — | 1 | 5.19 |
| CHEMBL3741151 | — | — | 1 | - |
| CHEMBL3742285 | — | — | 1 | - |
| CHEMBL3741177 | — | — | 1 | - |
| CHEMBL3740258 | — | — | 1 | - |
| CHEMBL3741250 | — | — | 1 | - |
| CHEMBL3740365 | — | — | 1 | - |
| CHEMBL3741066 | — | — | 1 | - |
| CHEMBL3742072 | — | — | 1 | - |
| CHEMBL3741453 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3741798 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3739786 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3741350 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3741270 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3739453 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3739840 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3742199 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3741475 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3741905 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3739628 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3741327 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3739780 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3739580 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3739684 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3741416 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3740656 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL3742250 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL3741742 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL3741635 | — | IC50 | = | 168.0 | nM | 6.78 |
| CHEMBL3739906 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL3741151 | — | IC50 | < | 8.0 | nM | - |
| CHEMBL3742285 | — | IC50 | < | 8.0 | nM | - |
| CHEMBL3741177 | — | IC50 | < | 8.0 | nM | - |
| CHEMBL3740258 | — | IC50 | < | 8.0 | nM | - |
| CHEMBL3741250 | — | IC50 | < | 8.0 | nM | - |
| CHEMBL3740365 | — | IC50 | < | 8.0 | nM | - |
| CHEMBL3741066 | — | IC50 | < | 8.0 | nM | - |
| CHEMBL3742072 | — | IC50 | < | 8.0 | nM | - |
| CHEMBL3741453 | — | IC50 | < | 8.0 | nM | - |