Assay Detail
Binding
CHEMBL3745493
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Inhibition of recombinant human COX-2 preincubated for 15 mins by fluorescence analysis
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and Evaluation of Novel Erlotinib-NSAID Conjugates as More Comprehensive Anticancer Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.23 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL571 | KETOPROFEN | 4.0 | 1 | 7.21 |
| CHEMBL12952 | — | — | 1 | 6.55 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 6.39 |
| CHEMBL521 | IBUPROFEN | 4.0 | 1 | 5.96 |
| CHEMBL15770 | SULINDAC | 4.0 | 1 | 5.06 |
| CHEMBL3741304 | — | — | 1 | - |
| CHEMBL3740595 | — | — | 1 | - |
| CHEMBL3740850 | — | — | 1 | - |
| CHEMBL3742059 | — | — | 1 | - |
| CHEMBL3741026 | — | — | 1 | - |
| CHEMBL3741424 | — | — | 1 | - |
| CHEMBL25 | ASPIRIN | 4.0 | 1 | - |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | - |
| CHEMBL3739528 | — | — | 1 | - |
| CHEMBL3739527 | — | — | 1 | - |
| CHEMBL3741768 | — | — | 1 | - |
| CHEMBL3739771 | — | — | 1 | - |
| CHEMBL3740105 | — | — | 1 | - |
| CHEMBL3741399 | — | — | 1 | - |
| CHEMBL3741490 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL571 | KETOPROFEN | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL12952 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL521 | IBUPROFEN | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL15770 | SULINDAC | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL3741304 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3740595 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3740850 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3742059 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3741026 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3741424 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL25 | ASPIRIN | IC50 | > | 10000.0 | nM | - |
| CHEMBL553 | ERLOTINIB | IC50 | > | 10000.0 | nM | - |
| CHEMBL3739528 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3739527 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3741768 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3739771 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3740105 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3741399 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3741490 | — | IC50 | > | 10000.0 | nM | - |