Assay Detail
Functional
CHEMBL3745585
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against HUVEC assessed as inhibition of human recombinant VEGF165-induced proliferation preincubated for 2 hrs followed by VEGF165 addition measured after 48 hrs by cell counting analysis
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of anilinopyrimidine-based naphthamide derivatives as potent VEGFR-2 inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 8.21 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3742328 | — | — | 1 | 9.70 |
| CHEMBL3740163 | — | — | 1 | 9.10 |
| CHEMBL3739633 | — | — | 1 | 9.10 |
| CHEMBL3741966 | — | — | 1 | 8.92 |
| CHEMBL491473 | CEDIRANIB | 3.0 | 1 | 8.92 |
| CHEMBL3739732 | — | — | 1 | 8.80 |
| CHEMBL3740673 | — | — | 1 | 8.80 |
| CHEMBL3741484 | — | — | 1 | 8.72 |
| CHEMBL3741316 | — | — | 1 | 8.70 |
| CHEMBL3740574 | — | — | 1 | 8.66 |
| CHEMBL3740781 | — | — | 1 | 8.62 |
| CHEMBL3741965 | — | — | 1 | 8.60 |
| CHEMBL3740276 | — | — | 1 | 8.48 |
| CHEMBL3740487 | — | — | 1 | 8.48 |
| CHEMBL3741413 | — | — | 1 | 8.38 |
| CHEMBL3739627 | — | — | 1 | 8.24 |
| CHEMBL3740087 | — | — | 1 | 8.17 |
| CHEMBL3741916 | — | — | 1 | 8.11 |
| CHEMBL3741311 | — | — | 1 | 8.09 |
| CHEMBL3739726 | — | — | 1 | 8.04 |
| CHEMBL3740554 | — | — | 1 | 8.03 |
| CHEMBL3741621 | — | — | 1 | 8.03 |
| CHEMBL3740721 | — | — | 1 | 8.01 |
| CHEMBL3739936 | — | — | 1 | 7.97 |
| CHEMBL3741625 | — | — | 1 | 7.86 |
| CHEMBL3740530 | — | — | 1 | 7.83 |
| CHEMBL3740788 | — | — | 1 | 7.72 |
| CHEMBL3741187 | — | — | 1 | 7.71 |
| CHEMBL3742168 | — | — | 1 | 7.59 |
| CHEMBL3739656 | — | — | 1 | 7.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3742328 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL3740163 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL3739633 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL3741966 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL491473 | CEDIRANIB | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL3739732 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL3740673 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL3741484 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL3741316 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3740574 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL3740781 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL3741965 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL3740276 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL3740487 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL3741413 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL3739627 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL3740087 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL3741916 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL3741311 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL3739726 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL3741621 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL3740554 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL3740721 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL3739936 | — | IC50 | = | 10.6 | nM | 7.97 |
| CHEMBL3741625 | — | IC50 | = | 13.7 | nM | 7.86 |
| CHEMBL3740530 | — | IC50 | = | 14.8 | nM | 7.83 |
| CHEMBL3740788 | — | IC50 | = | 19.1 | nM | 7.72 |
| CHEMBL3741187 | — | IC50 | = | 19.5 | nM | 7.71 |
| CHEMBL3742168 | — | IC50 | = | 25.6 | nM | 7.59 |
| CHEMBL3739656 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL3741592 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL3741411 | — | IC50 | = | 31.5 | nM | 7.50 |
| CHEMBL3741641 | — | IC50 | = | 32.2 | nM | 7.49 |
| CHEMBL3739569 | — | IC50 | = | 33.2 | nM | 7.48 |
| CHEMBL3740856 | — | IC50 | = | 41.8 | nM | 7.38 |
| CHEMBL3739572 | — | IC50 | = | 92.4 | nM | 7.03 |
| CHEMBL3740073 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL3739835 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL3741876 | — | IC50 | > | 100.0 | nM | - |