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Assay Detail

CHEMBL3748173

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Binding
Inhibition of transglycosylase activity of Escherichia coli PBP1b incubated for 30 mins by continous fluorescence assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Escherichia coli
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Structure-Activity Relationships of Novel Tryptamine-Based Inhibitors of Bacterial Transglycosylase.
Sosič I, Anderluh M, Sova M, Gobec M, Mlinarič Raščan I, Derouaux A, Amoroso A, Terrak M, Breukink E, Gobec S.
J Med Chem (2015) 58 : 9712 -9721
PubMed 26588190 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 4.37 4.68

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3745804 1 4.68
CHEMBL3746902 1 4.54
CHEMBL3746780 1 4.41
CHEMBL3747065 1 4.30
CHEMBL3746837 1 4.29
CHEMBL3747270 1 4.01
CHEMBL3747569 1 -
CHEMBL3747580 1 -
CHEMBL3747212 1 -
CHEMBL3747363 1 -
CHEMBL3746047 1 -
CHEMBL3746438 1 -
CHEMBL3745856 1 -
CHEMBL3746217 1 -
CHEMBL3746018 1 -
CHEMBL3746687 1 -
CHEMBL3747634 1 -
CHEMBL3747032 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3745804 IC50 = 21000.0 nM 4.68
CHEMBL3746902 IC50 = 29000.0 nM 4.54
CHEMBL3746780 IC50 = 39000.0 nM 4.41
CHEMBL3747065 IC50 = 50000.0 nM 4.30
CHEMBL3746837 IC50 = 51000.0 nM 4.29
CHEMBL3747270 IC50 = 97000.0 nM 4.01
CHEMBL3747569 IC50 > 250000.0 nM -
CHEMBL3747580 IC50 > 250000.0 nM -
CHEMBL3747212 IC50 = 166000.0 nM -
CHEMBL3747363 IC50 > 250000.0 nM -
CHEMBL3746047 IC50 > 250000.0 nM -
CHEMBL3746438 IC50 > 250000.0 nM -
CHEMBL3745856 IC50 > 250000.0 nM -
CHEMBL3746217 IC50 = 103000.0 nM -
CHEMBL3746018 IC50 = 193000.0 nM -
CHEMBL3746687 IC50 > 250000.0 nM -
CHEMBL3747634 IC50 = 104000.0 nM -
CHEMBL3747032 IC50 > 250000.0 nM -