Assay Detail
Binding
CHEMBL3748425
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Inhibition of human recombinant COX2 by enzyme immuno assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of new 1,3,5-triarylpyrazoline and 1,5-diarylpyrazole derivatives as selective COX-2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.63 | 6.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3747206 | — | — | 1 | 6.25 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 6.06 |
| CHEMBL3746265 | — | — | 1 | 6.01 |
| CHEMBL521 | IBUPROFEN | 4.0 | 1 | 5.96 |
| CHEMBL3746730 | — | — | 1 | 5.84 |
| CHEMBL3747437 | — | — | 1 | 5.82 |
| CHEMBL3747566 | — | — | 1 | 5.74 |
| CHEMBL3745861 | — | — | 1 | 5.71 |
| CHEMBL3747733 | — | — | 1 | 5.70 |
| CHEMBL3746878 | — | — | 1 | 5.68 |
| CHEMBL3747306 | — | — | 1 | 5.58 |
| CHEMBL3747612 | — | — | 1 | 5.45 |
| CHEMBL3747568 | — | — | 1 | 5.44 |
| CHEMBL3746930 | — | — | 1 | 5.41 |
| CHEMBL3745732 | — | — | 1 | 5.38 |
| CHEMBL3747777 | — | — | 1 | 5.36 |
| CHEMBL3746891 | — | — | 1 | 5.21 |
| CHEMBL3747561 | — | — | 1 | 5.21 |
| CHEMBL3746042 | — | — | 1 | 5.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3747206 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL118 | CELECOXIB | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL3746265 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL521 | IBUPROFEN | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3746730 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL3747437 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL3747566 | — | IC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL3745861 | — | IC50 | = | 1970.0 | nM | 5.71 |
| CHEMBL3747733 | — | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL3746878 | — | IC50 | = | 2110.0 | nM | 5.68 |
| CHEMBL3747306 | — | IC50 | = | 2640.0 | nM | 5.58 |
| CHEMBL3747612 | — | IC50 | = | 3560.0 | nM | 5.45 |
| CHEMBL3747568 | — | IC50 | = | 3650.0 | nM | 5.44 |
| CHEMBL3746930 | — | IC50 | = | 3890.0 | nM | 5.41 |
| CHEMBL3745732 | — | IC50 | = | 4130.0 | nM | 5.38 |
| CHEMBL3747777 | — | IC50 | = | 4330.0 | nM | 5.36 |
| CHEMBL3746891 | — | IC50 | = | 6110.0 | nM | 5.21 |
| CHEMBL3747561 | — | IC50 | = | 6110.0 | nM | 5.21 |
| CHEMBL3746042 | — | IC50 | = | 6340.0 | nM | 5.20 |