Assay Detail
Binding
CHEMBL3748719
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine brain tubulin polymerization by spectrophotometry
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Novel iodoacetamido benzoheterocyclic derivatives with potent antileukemic activity are inhibitors of STAT5 phosphorylation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.80 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3746143 | — | — | 1 | 5.96 |
| CHEMBL490384 | — | — | 1 | 5.75 |
| CHEMBL3747558 | — | — | 1 | 5.70 |
| CHEMBL3747491 | — | — | 1 | - |
| CHEMBL3745749 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3746143 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL490384 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3747558 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3747491 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3745749 | — | IC50 | > | 20000.0 | nM | - |