Assay Detail
Binding
CHEMBL3748723
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]1alpha,25-(OH)2D3 from full-length recombinant rat VDR by scintillation counter
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A Methylene Group on C-2 of 24,24-Difluoro-19-nor-1α,25-dihydroxyvitamin D3 Markedly Increases Bone Calcium Mobilization in Vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 10.51 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3745798 | — | — | 1 | 10.70 |
| CHEMBL3746107 | — | — | 1 | 10.52 |
| CHEMBL3746058 | — | — | 1 | 10.52 |
| CHEMBL1214620 | — | — | 1 | 10.52 |
| CHEMBL3746759 | — | — | 1 | 10.40 |
| CHEMBL846 | CALCITRIOL | 4.0 | 1 | 10.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3745798 | — | Ki | = | 0.02 | nM | 10.70 |
| CHEMBL3746107 | — | Ki | = | 0.03 | nM | 10.52 |
| CHEMBL3746058 | — | Ki | = | 0.03 | nM | 10.52 |
| CHEMBL1214620 | — | Ki | = | 0.03 | nM | 10.52 |
| CHEMBL3746759 | — | Ki | = | 0.04 | nM | 10.40 |
| CHEMBL846 | CALCITRIOL | Ki | = | 0.04 | nM | 10.40 |