Assay Detail
Functional
CHEMBL3748916
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Antiproliferative activity against human K562 cells after 72 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and Characterization of 4,11-Diaminoanthra[2,3-b]furan-5,10-diones: Tumor Cell Apoptosis through tNOX-Modulated NAD(+)/NADH Ratio and SIRT1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.23 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3746861 | — | — | 1 | 6.96 |
| CHEMBL3745930 | — | — | 1 | 6.96 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.92 |
| CHEMBL1652383 | — | — | 1 | 6.92 |
| CHEMBL3747757 | — | — | 1 | 6.92 |
| CHEMBL3747698 | — | — | 1 | 6.68 |
| CHEMBL3746814 | — | — | 1 | 5.78 |
| CHEMBL3747021 | — | — | 1 | 4.60 |
| CHEMBL3746842 | — | — | 1 | 4.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3746861 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3745930 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1652383 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3747757 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3747698 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3746814 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL3747021 | — | IC50 | = | 25170.0 | nM | 4.60 |
| CHEMBL3746842 | — | IC50 | = | 49460.0 | nM | 4.31 |