Assay Detail
Functional
CHEMBL3749449
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Antipoliferative activity against human MCF7 cells after 48 hrs by MTT assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel nonsecosteroidal VDR ligands with phenyl-pyrrolyl pentane skeleton for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 5.99 | 8.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3747184 | — | — | 1 | 8.23 |
| CHEMBL3747314 | — | — | 1 | 7.12 |
| CHEMBL3747394 | — | — | 1 | 6.80 |
| CHEMBL3747730 | — | — | 1 | 6.72 |
| CHEMBL3747675 | — | — | 1 | 6.47 |
| CHEMBL3746404 | — | — | 1 | 6.32 |
| CHEMBL3746465 | — | — | 1 | 6.31 |
| CHEMBL3747383 | — | — | 1 | 6.28 |
| CHEMBL3747341 | — | — | 1 | 6.28 |
| CHEMBL3746520 | — | — | 1 | 6.18 |
| CHEMBL3747640 | — | — | 1 | 6.16 |
| CHEMBL3746078 | — | — | 1 | 6.16 |
| CHEMBL3747703 | — | — | 1 | 5.70 |
| CHEMBL3746013 | — | — | 1 | 5.68 |
| CHEMBL2434990 | — | — | 1 | 5.55 |
| CHEMBL3747293 | — | — | 1 | 5.28 |
| CHEMBL846 | CALCITRIOL | 4.0 | 1 | 5.25 |
| CHEMBL197946 | — | — | 1 | 5.11 |
| CHEMBL3747701 | — | — | 1 | 5.04 |
| CHEMBL3746880 | — | — | 1 | 4.59 |
| CHEMBL3746130 | — | — | 1 | 4.54 |
| CHEMBL3745792 | — | — | 1 | - |
| CHEMBL3746653 | — | — | 1 | - |
| CHEMBL3747246 | — | — | 1 | - |
| CHEMBL3747642 | — | — | 1 | - |
| CHEMBL3747218 | — | — | 1 | - |
| CHEMBL3746817 | — | — | 1 | - |
| CHEMBL3747093 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3747184 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL3747314 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL3747394 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3747730 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL3747675 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL3746404 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL3746465 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL3747383 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL3747341 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL3746520 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL3747640 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL3746078 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL3747703 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3746013 | — | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL2434990 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL3747293 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL846 | CALCITRIOL | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL197946 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL3747701 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL3746880 | — | IC50 | = | 25400.0 | nM | 4.59 |
| CHEMBL3746130 | — | IC50 | = | 28600.0 | nM | 4.54 |
| CHEMBL3745792 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3746653 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3747246 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3747642 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3747218 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3746817 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3747093 | — | IC50 | > | 50000.0 | nM | - |