Assay Detail
Binding
CHEMBL3749743
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant Sulfurihydrogenibium yellowstonense YO3AOP1 carbonic anhydrase by stopped flow CO2 hydrase assay
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sulfurihydrogenibium yellowstonense |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Carbonate dehydratase (CHEMBL3745586) ↗| Type | SINGLE PROTEIN |
| Organism | Sulfurihydrogenibium sp. (strain YO3AOP1) |
Publication
Sulfonamide inhibition studies of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 40 | 7.31 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 8.35 |
| CHEMBL865 | VALDECOXIB | 4.0 | 1 | 8.28 |
| CHEMBL268439 | — | — | 1 | 8.26 |
| CHEMBL6633 | — | — | 1 | 8.19 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 8.18 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 8.16 |
| CHEMBL435 | HYDROCHLOROTHIAZIDE | 4.0 | 1 | 8.14 |
| CHEMBL328560 | SULTHIAME | 3.0 | 1 | 8.11 |
| CHEMBL266026 | — | — | 1 | 8.11 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 8.10 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 8.09 |
| CHEMBL73962 | BENZOLAMIDE | — | 1 | 8.09 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 8.07 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 8.03 |
| CHEMBL7146 | — | — | 1 | 8.01 |
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | 7.91 |
| CHEMBL7092 | — | — | 1 | 7.38 |
| CHEMBL268177 | — | — | 1 | 7.35 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | — | 1 | 7.21 |
| CHEMBL6685 | — | — | 1 | 7.18 |
| CHEMBL6853 | — | — | 1 | 7.17 |
| CHEMBL26 | SULPIRIDE | 3.0 | 1 | 7.17 |
| CHEMBL360356 | — | — | 1 | 7.15 |
| CHEMBL7087 | — | — | 1 | 7.14 |
| CHEMBL414 | CARZENIDE | 2.0 | 1 | 7.14 |
| CHEMBL6724 | — | — | 1 | 7.12 |
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 7.08 |
| CHEMBL266240 | — | — | 1 | 7.06 |
| CHEMBL265674 | — | — | 1 | 6.86 |
| CHEMBL750 | ZONISAMIDE | 4.0 | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL865 | VALDECOXIB | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL268439 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL6633 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL118 | CELECOXIB | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL435 | HYDROCHLOROTHIAZIDE | Ki | = | 7.2 | nM | 8.14 |
| CHEMBL328560 | SULTHIAME | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL266026 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL73962 | BENZOLAMIDE | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL7146 | — | Ki | = | 9.7 | nM | 8.01 |
| CHEMBL220491 | BRINZOLAMIDE | Ki | = | 12.3 | nM | 7.91 |
| CHEMBL7092 | — | Ki | = | 41.2 | nM | 7.38 |
| CHEMBL268177 | — | Ki | = | 44.8 | nM | 7.35 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | Ki | = | 61.2 | nM | 7.21 |
| CHEMBL6685 | — | Ki | = | 66.4 | nM | 7.18 |
| CHEMBL6853 | — | Ki | = | 68.3 | nM | 7.17 |
| CHEMBL26 | SULPIRIDE | Ki | = | 67.4 | nM | 7.17 |
| CHEMBL360356 | — | Ki | = | 70.1 | nM | 7.15 |
| CHEMBL7087 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL414 | CARZENIDE | Ki | = | 72.4 | nM | 7.14 |
| CHEMBL6724 | — | Ki | = | 75.7 | nM | 7.12 |
| CHEMBL77517 | INDISULAM | Ki | = | 84.1 | nM | 7.08 |
| CHEMBL266240 | — | Ki | = | 87.3 | nM | 7.06 |
| CHEMBL265674 | — | Ki | = | 137.0 | nM | 6.86 |
| CHEMBL750 | ZONISAMIDE | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL6784 | — | Ki | = | 162.0 | nM | 6.79 |
| CHEMBL419 | MAFENIDE | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL6753 | — | Ki | = | 433.0 | nM | 6.36 |
| CHEMBL6919 | — | Ki | = | 493.0 | nM | 6.31 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 652.0 | nM | 6.19 |
| CHEMBL176495 | — | Ki | = | 695.0 | nM | 6.16 |
| CHEMBL6705 | — | Ki | = | 707.0 | nM | 6.15 |
| CHEMBL7204 | — | Ki | = | 803.0 | nM | 6.09 |
| CHEMBL574 | P-TOLUENESULFONAMIDE | Ki | = | 848.0 | nM | 6.07 |
| CHEMBL310671 | SACCHARIN | Ki | = | 876.0 | nM | 6.06 |