Assay Detail
Binding
CHEMBL3749754
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of monophenolase activity of mushroom tyrosinase using L-tyrosine as substrate preincubated for 5 to 60 mins by Lineweaver-Burk and Dixon plot analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Agaricus bisporus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Highly potent tyrosinase inhibitor, neorauflavane from Campylotropis hirtella and inhibitory mechanism with molecular docking.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.72 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3747057 | — | — | 1 | 7.72 |
| CHEMBL3745886 | — | — | 1 | 5.75 |
| CHEMBL3746218 | — | — | 1 | 5.12 |
| CHEMBL3746757 | — | — | 1 | 4.30 |
| CHEMBL287556 | KOJIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3747057 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL3745886 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL3746218 | — | Ki | = | 7500.0 | nM | 5.12 |
| CHEMBL3746757 | — | Ki | = | 49700.0 | nM | 4.30 |
| CHEMBL287556 | KOJIC ACID | Ki | - | — | - |