Assay Detail
Binding
CHEMBL3750091
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Inhibition of human carbonic anhydrase 2
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimization of allosteric MEK inhibitors. Part 2: Taming the sulfamide group balances compound distribution properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.73 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3746142 | — | — | 1 | 6.30 |
| CHEMBL2376666 | — | — | 1 | 6.28 |
| CHEMBL3747256 | — | — | 1 | 6.16 |
| CHEMBL3747359 | — | — | 1 | 6.16 |
| CHEMBL2376667 | — | — | 1 | 5.89 |
| CHEMBL3746031 | — | — | 1 | 5.66 |
| CHEMBL3746923 | — | — | 1 | 5.55 |
| CHEMBL3747368 | — | — | 1 | 5.42 |
| CHEMBL3746559 | — | — | 1 | 5.34 |
| CHEMBL3746640 | — | — | 1 | 5.30 |
| CHEMBL3746516 | — | — | 1 | 5.00 |
| CHEMBL3746569 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3746142 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2376666 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL3747256 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3747359 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL2376667 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3746031 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL3746923 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL3747368 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL3746559 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL3746640 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3746516 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3746569 | — | IC50 | > | 10000.0 | nM | - |