Assay Detail
Binding
CHEMBL3750668
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP11B2 in human H285R cells assessed as decrease in [125I] angiotensin-2-induced aldosterone secretion after 24 hrs by RIA
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | H285R |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of N-[5-(6-Chloro-3-cyano-1-methyl-1H-indol-2-yl)-pyridin-3-ylmethyl]-ethanesulfonamide, a Cortisol-Sparing CYP11B2 Inhibitor that Lowers Aldosterone in Human Subjects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.61 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3747269 | — | — | 1 | 8.40 |
| CHEMBL3747562 | — | — | 1 | 8.24 |
| CHEMBL3746080 | — | — | 1 | 8.15 |
| CHEMBL3747584 | — | — | 1 | 8.05 |
| CHEMBL3747069 | — | — | 1 | 7.89 |
| CHEMBL3746125 | — | — | 1 | 7.68 |
| CHEMBL3746175 | — | — | 1 | 7.41 |
| CHEMBL3746868 | — | — | 1 | 7.05 |
| CHEMBL3747503 | — | — | 1 | 6.77 |
| CHEMBL3746924 | — | — | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3747269 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3747562 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL3746080 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3747584 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3747069 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3746125 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3746175 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3746868 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3747503 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL3746924 | — | IC50 | = | 380.0 | nM | 6.42 |