Assay Detail
Binding
CHEMBL3750669
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant CYP11B2 using 11-deoxycorticosterone as substrate after 2 hrs by scintillation proximity assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of N-[5-(6-Chloro-3-cyano-1-methyl-1H-indol-2-yl)-pyridin-3-ylmethyl]-ethanesulfonamide, a Cortisol-Sparing CYP11B2 Inhibitor that Lowers Aldosterone in Human Subjects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.48 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3099695 | OSILODROSTAT | 4.0 | 1 | 9.15 |
| CHEMBL3746080 | — | — | 1 | 8.96 |
| CHEMBL3747584 | — | — | 1 | 8.85 |
| CHEMBL3746175 | — | — | 1 | 8.70 |
| CHEMBL3747269 | — | — | 1 | 8.60 |
| CHEMBL3746125 | — | — | 1 | 8.52 |
| CHEMBL3747562 | — | — | 1 | 8.43 |
| CHEMBL3746868 | — | — | 1 | 7.96 |
| CHEMBL3747069 | — | — | 1 | 7.96 |
| CHEMBL3747503 | — | — | 1 | 7.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3099695 | OSILODROSTAT | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL3746080 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL3747584 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL3746175 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3747269 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL3746125 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3747562 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL3746868 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3747069 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3747503 | — | IC50 | = | 22.0 | nM | 7.66 |