Assay Detail
Binding
CHEMBL3750823
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP11B2 in cynomolgus monkey adrenal homogenates assessed as inhibition of aldosterone secretion
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Macaca fascicularis |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of N-[5-(6-Chloro-3-cyano-1-methyl-1H-indol-2-yl)-pyridin-3-ylmethyl]-ethanesulfonamide, a Cortisol-Sparing CYP11B2 Inhibitor that Lowers Aldosterone in Human Subjects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.04 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3746080 | — | — | 1 | 8.22 |
| CHEMBL3746868 | — | — | 1 | 8.05 |
| CHEMBL3747562 | — | — | 1 | 8.00 |
| CHEMBL3747069 | — | — | 1 | 7.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3746080 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3746868 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3747562 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3747069 | — | IC50 | = | 13.0 | nM | 7.89 |