Assay Detail
Functional
CHEMBL3750898
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Agonist activity at wild-type human CCK1R expressed in CHO cells assessed as intracellular calcium response by fluorescence analysis
4
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Molecular Mechanism of Action of Triazolobenzodiazepinone Agonists of the Type 1 Cholecystokinin Receptor. Possible Cooperativity across the Receptor Homodimeric Complex.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 9.09 | 9.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2017835 | — | — | 2 | 9.47 |
| CHEMBL1269258 | CE-326597 | 2.0 | 2 | 8.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2017835 | — | EC50 | = | 0.3388 | nM | 9.47 |
| CHEMBL2017835 | — | EC50 | = | 0.47 | nM | 9.33 |
| CHEMBL1269258 | CE-326597 | EC50 | = | 1.514 | nM | 8.82 |
| CHEMBL1269258 | CE-326597 | EC50 | = | 1.8 | nM | 8.74 |