Assay Detail
Binding
CHEMBL3751024
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Displacement of [125I-CCK] from wild-type human CCK1R expressed in CHO cells after 60 mins by scintillation counter
6
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Molecular Mechanism of Action of Triazolobenzodiazepinone Agonists of the Type 1 Cholecystokinin Receptor. Possible Cooperativity across the Receptor Homodimeric Complex.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.56 | 7.65 |
| Ki | 2 | 6.62 | 6.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1269258 | CE-326597 | 2.0 | 3 | 7.65 |
| CHEMBL2017835 | — | — | 3 | 7.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1269258 | CE-326597 | IC50 | = | 22.39 | nM | 7.65 |
| CHEMBL1269258 | CE-326597 | IC50 | = | 26.8 | nM | 7.57 |
| CHEMBL2017835 | — | IC50 | = | 27.54 | nM | 7.56 |
| CHEMBL2017835 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL2017835 | — | Ki | = | 213.8 | nM | 6.67 |
| CHEMBL1269258 | CE-326597 | Ki | = | 275.42 | nM | 6.56 |