Assay Detail
Functional
CHEMBL3751611
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Antiproliferative activity against human K562 cells after 48 hrs by trypan blue dye exclusion assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel iodoacetamido benzoheterocyclic derivatives with potent antileukemic activity are inhibitors of STAT5 phosphorylation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.94 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3745809 | — | — | 1 | 7.16 |
| CHEMBL490384 | — | — | 1 | 6.92 |
| CHEMBL941 | IMATINIB | 4.0 | 1 | 6.66 |
| CHEMBL3746143 | — | — | 1 | 6.40 |
| CHEMBL3746602 | — | — | 1 | 6.40 |
| CHEMBL3747534 | — | — | 1 | 6.40 |
| CHEMBL3747015 | — | — | 1 | 6.30 |
| CHEMBL3747414 | — | — | 1 | 6.22 |
| CHEMBL3747336 | — | — | 1 | 6.22 |
| CHEMBL3099855 | — | — | 1 | 6.11 |
| CHEMBL3099852 | — | — | 1 | 6.10 |
| CHEMBL3747558 | — | — | 1 | 6.10 |
| CHEMBL3747203 | — | — | 1 | 6.10 |
| CHEMBL3747491 | — | — | 1 | 6.05 |
| CHEMBL3745749 | — | — | 1 | 6.00 |
| CHEMBL3746039 | — | — | 1 | 6.00 |
| CHEMBL3745727 | — | — | 1 | 5.54 |
| CHEMBL3746922 | — | — | 1 | 5.50 |
| CHEMBL3747583 | — | — | 1 | 5.37 |
| CHEMBL3745826 | — | — | 1 | 4.85 |
| CHEMBL3746288 | — | — | 1 | 4.75 |
| CHEMBL3747594 | — | — | 1 | 4.75 |
| CHEMBL3747442 | — | — | 1 | 4.66 |
| CHEMBL3746092 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3745809 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL490384 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL941 | IMATINIB | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL3746143 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3746602 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3747534 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3747015 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3747414 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3747336 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3099855 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL3099852 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3747558 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3747203 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3747491 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3745749 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3746039 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3745727 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL3746922 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL3747583 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL3745826 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL3746288 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL3747594 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL3747442 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL3746092 | — | IC50 | > | 50000.0 | nM | - |