Assay Detail
Binding
CHEMBL3755067
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human BACE-1 using M-2420 as substrate preincubated for 1 hr followed by substrate addition measured after 15 mins by FRET assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.29 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3753957 | — | — | 1 | 6.72 |
| CHEMBL3752926 | — | — | 1 | 6.37 |
| CHEMBL3753360 | — | — | 1 | 6.21 |
| CHEMBL3752467 | — | — | 1 | 5.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3753957 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL3752926 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL3753360 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL3752467 | — | IC50 | = | 1350.0 | nM | 5.87 |