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Assay Detail

CHEMBL3755177

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Saccharomyces cerevisiae alpha-Glucosidase using p-nitrophenyl-alpha-D-glucopyranoside as substrate assessed as formation of para-nitrophenol preincubated for 5 mins followed by addition of substrate measured after 15 mins by microplate reader analysis
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Saccharomyces cerevisiae
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Polyketide butenolide, diphenyl ether, and benzophenone derivatives from the fungus Aspergillus flavipes PJ03-11.
Zhang LH, Feng BM, Zhao YQ, Sun Y, Liu B, Liu F, Chen G, Bai J, Hua HM, Wang HF, Pei YH.
Bioorg Med Chem Lett (2016) 26 : 346 -350
PubMed 26706176 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 6.79 7.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL50 QUERCETIN 3.0 1 7.82
CHEMBL3752482 1 7.80
CHEMBL3752326 1 7.66
CHEMBL2035566 1 7.38
CHEMBL3753780 1 7.10
CHEMBL2035564 GEODIN HYDRATE 1 7.04
CHEMBL3753562 1 6.90
CHEMBL61045 1 6.70
CHEMBL3753427 1 6.42
CHEMBL4299399 1 6.16
CHEMBL511994 METYL DICHLOROASTERRATE 1 5.84
CHEMBL3754330 1 5.83
CHEMBL2337339 ASPULVINONE E 1 5.57
CHEMBL469424 ASTERRIC ACID 1 -
CHEMBL3754161 1 -
CHEMBL3752836 1 -
CHEMBL3752785 1 -
CHEMBL3754623 1 -
CHEMBL471279 METHYL CHLOROASTERRATE 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL50 QUERCETIN IC50 = 15.0 nM 7.82
CHEMBL3752482 IC50 = 16.0 nM 7.80
CHEMBL3752326 IC50 = 22.0 nM 7.66
CHEMBL2035566 IC50 = 42.0 nM 7.38
CHEMBL3753780 IC50 = 79.0 nM 7.10
CHEMBL2035564 GEODIN HYDRATE IC50 = 91.0 nM 7.04
CHEMBL3753562 IC50 = 126.0 nM 6.90
CHEMBL61045 IC50 = 199.0 nM 6.70
CHEMBL3753427 IC50 = 385.0 nM 6.42
CHEMBL4299399 IC50 = 685.0 nM 6.16
CHEMBL511994 METYL DICHLOROASTERRATE IC50 = 1452.0 nM 5.84
CHEMBL3754330 IC50 = 1476.0 nM 5.83
CHEMBL2337339 ASPULVINONE E IC50 = 2700.0 nM 5.57
CHEMBL469424 ASTERRIC ACID IC50 > 2000.0 nM -
CHEMBL3754161 IC50 > 2000.0 nM -
CHEMBL3752836 IC50 > 2000.0 nM -
CHEMBL3752785 IC50 > 2000.0 nM -
CHEMBL3754623 IC50 > 2000.0 nM -
CHEMBL471279 METHYL CHLOROASTERRATE IC50 > 2000.0 nM -