Assay Detail
Binding
CHEMBL3755426
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human MAP4K4 catalytic domain in presence of 10 uM ATP (Km) by FRET assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mitogen-activated protein kinase kinase kinase kinase 4 (CHEMBL6166) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic Treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.10 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3754515 | — | — | 1 | 8.43 |
| CHEMBL3753424 | — | — | 1 | 7.89 |
| CHEMBL3754123 | — | — | 1 | 7.83 |
| CHEMBL3754730 | — | — | 1 | 7.70 |
| CHEMBL3754283 | — | — | 1 | 7.68 |
| CHEMBL3752854 | — | — | 1 | 7.35 |
| CHEMBL3754588 | — | — | 1 | 7.34 |
| CHEMBL3752433 | — | — | 1 | 7.32 |
| CHEMBL3754304 | — | — | 1 | 7.19 |
| CHEMBL3753371 | — | — | 1 | 7.08 |
| CHEMBL3752536 | — | — | 1 | 7.03 |
| CHEMBL3754762 | — | — | 1 | 7.02 |
| CHEMBL3754611 | — | — | 1 | 6.61 |
| CHEMBL3753891 | — | — | 1 | 6.57 |
| CHEMBL3754522 | — | — | 1 | 6.07 |
| CHEMBL3753160 | — | — | 1 | 5.82 |
| CHEMBL3752670 | — | — | 1 | 5.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3754515 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL3753424 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3754123 | — | IC50 | = | 14.9 | nM | 7.83 |
| CHEMBL3754730 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3754283 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3752854 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL3754588 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL3752433 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL3754304 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL3753371 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL3752536 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL3754762 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL3754611 | — | IC50 | = | 248.0 | nM | 6.61 |
| CHEMBL3753891 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL3754522 | — | IC50 | = | 861.0 | nM | 6.07 |
| CHEMBL3753160 | — | IC50 | = | 1509.0 | nM | 5.82 |
| CHEMBL3752670 | — | IC50 | = | 1722.0 | nM | 5.76 |