Assay Detail
Binding
CHEMBL3755427
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human MAP4K4 transfected in 293 MSR cells assessed as inhibition of phosphorylation of traf2 at ser/thr residue by ELISA
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mitogen-activated protein kinase kinase kinase kinase 4 (CHEMBL6166) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic Treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.82 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3754515 | — | — | 1 | 6.80 |
| CHEMBL3753424 | — | — | 1 | 6.44 |
| CHEMBL3754123 | — | — | 1 | 6.33 |
| CHEMBL3754730 | — | — | 1 | 6.23 |
| CHEMBL3752854 | — | — | 1 | 6.22 |
| CHEMBL3754762 | — | — | 1 | 5.54 |
| CHEMBL3754283 | — | — | 1 | 5.54 |
| CHEMBL3754304 | — | — | 1 | 5.38 |
| CHEMBL3752433 | — | — | 1 | 5.21 |
| CHEMBL3752536 | — | — | 1 | 5.20 |
| CHEMBL3754588 | — | — | 1 | 5.12 |
| CHEMBL3753371 | — | — | 1 | - |
| CHEMBL3752670 | — | — | 1 | - |
| CHEMBL3754522 | — | — | 1 | - |
| CHEMBL3753160 | — | — | 1 | - |
| CHEMBL3753891 | — | — | 1 | - |
| CHEMBL3754611 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3754515 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3753424 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL3754123 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL3754730 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL3752854 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3754762 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL3754283 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL3754304 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL3752433 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL3752536 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL3754588 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL3753371 | — | IC50 | - | — | - | |
| CHEMBL3752670 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3754522 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3753160 | — | IC50 | - | — | - | |
| CHEMBL3753891 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3754611 | — | IC50 | > | 30000.0 | nM | - |