Assay Detail
Binding
CHEMBL3755458
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant mouse NAMPT expressed in bacteria assessed as reduction in NADH formation using [14C]NAM as substrate measured for 1 hr by coupled enzymatic assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nicotinamide phosphoribosyltransferase (CHEMBL3259474) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Identification of a novel NAMPT inhibitor by combinatorial click chemistry and chemical refinement
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.87 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL566757 | DAPORINAD | 2.0 | 1 | 7.21 |
| CHEMBL3753643 | — | — | 1 | 6.94 |
| CHEMBL3752157 | — | — | 1 | 6.77 |
| CHEMBL3753517 | — | — | 1 | 6.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL566757 | DAPORINAD | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL3753643 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL3752157 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3753517 | — | IC50 | = | 267.0 | nM | 6.57 |