Assay Detail
Binding
CHEMBL3755460
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NAMPT in human SH-SY5Y cells assessed as NAD depletion incubated for 16 hrs
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SH-SY5Y |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nicotinamide phosphoribosyltransferase (CHEMBL1744525) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of a novel NAMPT inhibitor by combinatorial click chemistry and chemical refinement
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 9.47 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL566757 | DAPORINAD | 2.0 | 1 | 10.52 |
| CHEMBL3753643 | — | — | 1 | 10.29 |
| CHEMBL3753517 | — | — | 1 | 8.96 |
| CHEMBL3752157 | — | — | 1 | 8.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL566757 | DAPORINAD | IC50 | = | 0.0301 | nM | 10.52 |
| CHEMBL3753643 | — | IC50 | = | 0.0509 | nM | 10.29 |
| CHEMBL3753517 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL3752157 | — | IC50 | = | 7.6 | nM | 8.12 |