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Assay Detail

CHEMBL3755480

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of alpha-glucosidase (unknown origin) using p-nitrophenyl glucopyranoside as substrate preincubated for 10 mins followed by substrate addition measured after 30 mins by plate reader analysis
26
Total Activities
26
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Novel quinoline derivatives as potent in vitro -glucosidase inhibitors: in silico studies and SAR predictions
Taha M, Ismail NH, Imran S, Wadood A, Rahim F, Ali M, Rehman AU
Medchemcomm (2015) 6 : 1826 -1836
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 4.87 5.58
Inhibition 2 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3752822 1 5.58
CHEMBL3752531 1 5.58
CHEMBL3752708 1 5.54
CHEMBL3752289 1 5.41
CHEMBL3752418 1 5.38
CHEMBL3752924 1 5.21
CHEMBL3752829 1 5.17
CHEMBL3753113 1 5.09
CHEMBL3751995 1 5.07
CHEMBL3753443 1 5.07
CHEMBL3754313 1 5.04
CHEMBL3753990 1 4.82
CHEMBL3753775 1 4.67
CHEMBL3753591 1 4.57
CHEMBL3752203 1 4.52
CHEMBL3752933 1 4.44
CHEMBL3752015 1 4.43
CHEMBL4299399 1 4.42
CHEMBL3753455 1 4.41
CHEMBL3754671 1 4.39
CHEMBL3753145 1 4.20
CHEMBL3754237 1 4.10
CHEMBL3752133 1 -
CHEMBL3752884 1 -
CHEMBL3751891 1 -
CHEMBL3753060 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3752822 IC50 = 2600.0 nM 5.58
CHEMBL3752531 IC50 = 2600.0 nM 5.58
CHEMBL3752708 IC50 = 2860.0 nM 5.54
CHEMBL3752289 IC50 = 3900.0 nM 5.41
CHEMBL3752418 IC50 = 4160.0 nM 5.38
CHEMBL3752924 IC50 = 6200.0 nM 5.21
CHEMBL3752829 IC50 = 6800.0 nM 5.17
CHEMBL3753113 IC50 = 8120.0 nM 5.09
CHEMBL3751995 IC50 = 8500.0 nM 5.07
CHEMBL3753443 IC50 = 8450.0 nM 5.07
CHEMBL3754313 IC50 = 9200.0 nM 5.04
CHEMBL3753990 IC50 = 15160.0 nM 4.82
CHEMBL3753775 IC50 = 21200.0 nM 4.67
CHEMBL3753591 IC50 = 27150.0 nM 4.57
CHEMBL3752203 IC50 = 30150.0 nM 4.52
CHEMBL3752933 IC50 = 36500.0 nM 4.44
CHEMBL3752015 IC50 = 37150.0 nM 4.43
CHEMBL4299399 IC50 = 38250.0 nM 4.42
CHEMBL3753455 IC50 = 39160.0 nM 4.41
CHEMBL3754671 IC50 = 40460.0 nM 4.39
CHEMBL3753145 IC50 = 63500.0 nM 4.20
CHEMBL3754237 IC50 = 80140.0 nM 4.10
CHEMBL3752133 Inhibition < 50.0 % -
CHEMBL3752884 Inhibition < 50.0 % -
CHEMBL3751891 IC50 = 102120.0 nM -
CHEMBL3753060 IC50 = 100460.0 nM -